Which ion is considered the main driver of aqueous production?

The main driver of aqueous humor production in the eye is bicarbonate ion (HCO3-). In the process of aqueous humor formation, the ciliary epithelium utilizes bicarbonate ions actively transported into the posterior chamber.

The secretion of bicarbonate creates an osmotic gradient that draws water into the aqueous humor, significantly contributing to its production. The presence of bicarbonate not only helps in maintaining the proper ionic composition of the aqueous humor but also plays a crucial role in creating the necessary conditions for the transport of essential nutrients and waste products.

While other ions like sodium may be involved in regulating fluid movement and maintaining osmotic balance, bicarbonate is specifically pivotal in stimulating the production of aqueous humor by enhancing the movement of water, thus establishing its primary role in this physiological process.