Which component of the ERG is specifically linked to the function of Müller and bipolar cells?

The B wave of the electroretinogram (ERG) is specifically associated with the function of Müller cells and bipolar cells. This wave reflects the activity of the inner retinal layers in response to light stimulation.

When light stimulates photoreceptors, they generate a response that is transmitted to bipolar cells. Bipolar cells are responsible for relaying the signal to ganglion cells, and their activity results in the generation of the B wave in the ERG. Müller cells, which are the primary retinal glial cells, also play a role in supporting retinal structure and function, contributing to the overall response seen in the B wave.

The B wave is characterized by its positive deflection following the A wave, which primarily reflects the activity of the photoreceptors (rods and cones) as well as the outer segments of the retina. This distinct relationship highlights the layer-specific contributions of different cell types in the retina to the overall visual signal measured by the ERG. Understanding this link between the B wave and the physiological roles of Müller and bipolar cells is fundamental for interpreting ERG recordings and assessing retinal function.