Is the corneal epithelium hydrophilic or hydrophobic?

The corneal epithelium is classified as hydrophobic primarily due to the nature of the lipids present in its outermost layer. This layer, composed of a lipid-rich tear film, creates a barrier that minimizes water penetration and helps maintain the eye's overall moisture balance. The hydrophobic properties of the corneal epithelium are essential for its function, as they contribute to the prevention of excessive tear evaporation and protect the underlying tissues from environmental factors.

In addition, the cell membranes of the epithelial cells contain phospholipids that add to their hydrophobic character, allowing them to repel water. This quality is crucial for maintaining the integrity of the corneal surface and ensuring that the eye remains protected and hydrated.

While some components within the cornea may have amphipathic characteristics, the predominant behavior of the corneal epithelium as a whole is hydrophobic, making it a crucial aspect of ocular physiology.