Does the concentration of hyaluronic acid in the vitreous increase or decrease with age?

The concentration of hyaluronic acid in the vitreous humor actually decreases with age. Hyaluronic acid is a vital component that contributes to the structure and viscosity of the vitreous body. As individuals age, the synthesis of hyaluronic acid often diminishes, leading to a reduction in its concentration within the vitreous. This reduction can affect the gel-like consistency of the vitreous, potentially leading to changes such as liquefaction, which may increase the risk of conditions like posterior vitreous detachment.

Understanding this process is crucial for recognizing the overall changes that occur in the vitreous with aging and their potential impact on ocular health.